|In vitro biotransformatie van organohalogeenverbindingen in zeezoogdieren en vogels. Mogelijke gevolgen voor bioaccumulatie en genotoxiciteit: 4. Polychloor terfenylen (PCT's)|
Boon, J.P.; Smith, D.E.C.; Lewis, W.E.; Klamer, H.J.C.; Pastor, D.; Wester, P.G.; de Boer, J. (1998). In vitro biotransformatie van organohalogeenverbindingen in zeezoogdieren en vogels. Mogelijke gevolgen voor bioaccumulatie en genotoxiciteit: 4. Polychloor terfenylen (PCT's). BEON Rapport = BEON-report, 98(1). RIKZ: Den Haag. 38 pp.
Part of: BEON Rapport = BEON-report. Programma Bureau BEON: Den Haag. ISSN 0924-6576, more
|Authors|| || Top |
- Boon, J.P., more
- Smith, D.E.C.
- Lewis, W.E.
- Klamer, H.J.C., more
- Pastor, D.
- Wester, P.G.
- de Boer, J., more
The in-vitrobiotransformation capacity of hepatic microsomes of a sperm whale (Physeter macrocephalus), a white beaked dolphin (Lagenorhynchus albirostris), a harbour seal (Phoca vitulina), and an eider duck (Somateria mollissima) for the polychlorinated terphenyl (PCT) mixture Aroclor 5442 (A5442) was investigated. The biotransformation rates for PCTs were generally low. Eider duck microsomes metabolised more of the early eluting PCTs, whereas the harbour seal microsomes metabolised a wider range of PCTs. The microsomes of the whitebeaked dolphin and the sperm whale were both almost incapable of metabolising any PCTs. The PCBs present as contamination in the A5442 mixture, were more readily metabolised than the PCTs. PCTs may therefore be more bioaccumulative than PBCs. On the other hand, molecular size of the PCTs may inhibit their bioaccumulation, especially for the octa- and higher chlorinated terphenyls. PCT residues could be detected in most of the wildlife samples. Hexa- and heptachlorinated congeners dominated. The highest concentrations were found in liver of eider ducks and in blubber of a whitebeaked dolphin. Relatively low, but still detectable, concentrations were found in blubber of three sperm whales. Because these animals do normally not occur in shelf seas, this strongly indicates that PCTs have also reached the deep sea. A5442 was not genotoxic in the mutatox assay.