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Competitive induction and enhancement of indole and a diketopiperazine in marine bacteria
Trischman, J.A.; Oeffner, R.E.; de Luna, M.G.; Kazaoka, M. (2004). Competitive induction and enhancement of indole and a diketopiperazine in marine bacteria. Mar. Biotechnol. 6(3): 215-220. dx.doi.org/10.1007/s10126-003-0010-z
In: Marine Biotechnology. Springer-Verlag: New York. ISSN 1436-2228, more
Peer reviewed article  

Available in Authors 

Keywords
    Antibiotics; Production; Production; Production; Marine

Authors  Top 
  • Trischman, J.A.
  • Oeffner, R.E.
  • de Luna, M.G.
  • Kazaoka, M.

Abstract
    Thirteen bacterial strains isolated from a sample of Ulva californica were cultured, extracted, and assayed for antibiotic activity. The target strains were 2 gram-positive isolates from the same algal sample. When cultured in monoculture, 2 of the 13 isolates produced extracts with antimicrobial activity. More significantly, one Bacillus isolate (UA-094) produced indole and cyclo(Phe-Pro) at active levels upon challenge with a different Bacillus target strain. These mildly antibiotic compounds were barely detectable in extracts without challenge. This technique of competitive induction and enhancement could be a valuable tool in the search for new antibiotics.

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