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The pharmacology of receptors present on squid giant axon Schwann cells
Evans, P.D.; Reale, V.; Merzon, R.M.; Villegas, J. (1995). The pharmacology of receptors present on squid giant axon Schwann cells, in: Abbott, N.J. et al. (Ed.) Cephalopod neurobiology: neuroscience studies in squid, octopus and cuttlefish. pp. 213-228
In: Abbott, N.J.; Williamson, R.; Maddock, L. (Ed.) (1995). Cephalopod neurobiology: neuroscience studies in squid, octopus and cuttlefish. Oxford University Press: London. ISBN 0-19-854790-0. 542 pp., more

Available in  Authors 
    VLIZ: Mollusca [8440]

Keyword
    Marine

Authors  Top 
  • Evans, P.D.
  • Reale, V.
  • Merzon, R.M.
  • Villegas, J.

Abstract
    The adaxonal Schwann cells of the squid giant axon possess a range of receptors for classical neurotransmitters. When activated these receptors either alter the membrane potential of the Schwann cell or modulate its responsiveness to other inputs. A complex cascade of events is involved in signalling between the giant axon and its surrounding Schwann cells, involving the release of glutamate from the axon, to act on receptors on the Schwann cells which mediate a release of endogenous acetylcholine. The latter molecule then feeds back to activate nicotinic cholinergic receptors on the Schwann cells which initiate the production of a long-lasting hyperpolarization of the Schwann cell membrane. The modulation of this cascade of events by a range of biogenic amines and neuropeptides will be reviewed. Recent evidence for the presence of both N-methyl-D-aspartate (NMDA) and non-NMDA type glutamate receptors on the Schwann cells will be discussed, together with evidence for the presence of an active uptake system for L-glutamate in this preparation. The co-release of acetylcholine and a vasoactive intestinal polypeptide (VIP)-like peptide from the Schwann cells will also be considered. Finally, the physiological roles of the different receptor systems present on the Schwann cells will be discussed.

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