ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Bisphenol A
Study details
Groupmammalian
OrganismFischer 344 rat, female
TissueVaginal epithelium
Age10-12 weeks
InVivoIn vivo
LabLaboratory
Flow
Duration
RouteIntraperitoneal
Temperature
ConcentrationED50 = 37.5 mg/kg body weight
NotesIn vitro detection of in vivo exposed animals
Described effects
Effect on estrogen: Induction of estrogen-mediated gene transcription
Literature references
Long, X., Steinmetz, R., Ben-Jonathan, N., Caperell-Grant, A., Young, P.C.M., Nephew, K.P., Bigsby, R.M.(2000). Strain differences in vaginal responses to the xenoestrogen bisphenol A.Environ. Health Perspect., 108(suppl 3): 243-247
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.