ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Bisphenol A
Study details
Groupmammalian
OrganismF344 rat, female
Tissue
Age6 weeks
InVivoIn vivo
LabLaboratory
Flow
Duration50 days
RouteIntraperitoneal
Temperature
Concentration0.1-10 mg/organism
NotesDosing 3 times weekly; ovariectomized rats grafted with rat pituitary tumor cells (MtT/E-2)
Described effects
Effect on estrogen: Dose dependent tumor development
Literature references
Maruyama, S., Fujimoto, N., Yin, H., Ito, A.(1999). Growth stimulation of a rat pituitary cell line MtT/E-2 by environmental estrogens in vitro and in vivo.Endocr. J., 46: 513-520
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.