ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Bisphenol A
Study details
Groupmammalian
OrganismHuman
TissueERalpha
Age
InVivoIn vitro
LabLaboratory
Flow
Duration24 hours
Route
Temperature
Concentration1-1000 nM
NotesHeLa cells transfected with hERalpha
Described effects
Effect on estrogen: Induction of ERalpha-mediated transcription
Effect on estrogen: 1-100 nM in combination with 10 nM 17-beta-estradiol: agonist
Effect on estrogen: 1 µM in combination with 10 nM 17-beta-estradiol: antagonist
Literature references
Hiroi, H., Tsutsumi, O., Momoeda, M., Takai, Y., Osuga, Y., Taketani, Y.(1999). Differential interactions of bisphenol A and 17-beta-estradiol with estrogen receptor alpha (ERalpha) and ERbeta.Endocr. J., 46: 773-778
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.