ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Bisphenol A
Study details
Groupmammalian
OrganismHuman
TissueERalpha
Age
InVivoIn vitro
LabLaboratory
Flow
Duration24 hours
Route
Temperature
ConcentrationEC50 = 218 nM
NotesHuman HepG2 hepatoma cells transfected with Eralpha
Described effects
Effect on estrogen: Activation of ERalpha
Effect on estrogen: Potency compared to 17-beta-estradiol: 0.038
Literature references
Gould, J.C., Leonard, L.S., Maness, S.C., Wagner, B.L., Conner, K., Zacharewski, T., Safe, S., McDonnell, D.P., Gaido, K.W.(1998). Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.Mol. Cell. Endocrinol., 142: 203-214
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.