ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Bisphenol A
Study details
Groupmammalian
OrganismRat
TissueERalpha
Age
InVivoIn vitro
LabLaboratory
Flow
Duration24 hours
Route
Temperature
ConcentrationEC50 = 210 nM
NotesHuman HepG2 hepatoma cells transfected with rat Eralpha
Described effects
Effect on estrogen: Activation of ERalpha
Literature references
Gould, J.C., Leonard, L.S., Maness, S.C., Wagner, B.L., Conner, K., Zacharewski, T., Safe, S., McDonnell, D.P., Gaido, K.W.(1998). Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.Mol. Cell. Endocrinol., 142: 203-214
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.