ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
home login contact pictures
 
planning background results databases partners users
ED North Database
Bisphenol A
Study details
Groupmammalian
OrganismSprague-Dawley rat, female
TissueUterus
Age21 days
InVivoIn vivo
LabLaboratory
Flow
Duration3 days
RouteOral
Temperature
Concentration100-150 mg/kg/day
NotesUterotrophic assay; dose range: 5-150 mg/kg
Described effects
Effect on estrogen: Increased peroxidase activity (estrogen-responsive)
Literature references
Gould, J.C., Leonard, L.S., Maness, S.C., Wagner, B.L., Conner, K., Zacharewski, T., Safe, S., McDonnell, D.P., Gaido, K.W.(1998). Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.Mol. Cell. Endocrinol., 142: 203-214
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.