ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Bisphenol A
Study details
Groupmammalian
OrganismWistar rat, female
Tissue
Age60-67 days
InVivoIn vivo
LabLaboratory
Flow
Duration7 days
RouteSubcutaneous
Temperature22°C
Concentration11-250 mg/kg/day
NotesOvariectomized rats
Described effects
Effect on estrogen: Dose-dependent uterotrophic activity
Effect on estrogen: 128-250 mg/kg: dose-dependent pituitary gland hypertrophy
Effect on pituitary hormone: 128-250 mg/kg: dose-dependent hyperprolactinaemia
Literature references
Goloubkova, T., Ribeiro, M.F.M., Rodrigues, L.P., Cecconello, A.L., Spritzer, P.M.(2000). Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats.Arch. Toxicol., 74: 92-98
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.