ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
home login contact pictures
 
planning background results databases partners users
ED North Database
Bisphenol A
Study details
Groupmammalian
OrganismB6C3F1 mouse, female
TissueUterus
Age35-60 days
InVivoIn vivo
LabLaboratory
Flow
Duration4 days
RouteSubcutaneous
Temperature23°C
Concentration0.02-8 mg/day
NotesOvariectomized mice
Described effects
Effect on estrogen: Increased mean uterus wet weight (EC50 = 0.72 mg/day)
Effect on estrogen: 2 mg/day: increased luminal epithelial height and thickness of stromal and myometrial layers
Literature references
Papaconstantinou, A.D., Umbreit, T.H., Fisher, B.R., Goering, P.L., Lappas, N.T., Brown, K.M.(2000). Bisphenol A-induced increase in uterine weight and alterations in uterine morphology in ovariectomized B6C3F1 mice: role of the estrogen receptor.Toxicol. Sci., 56: 332-339
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.