ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Bisphenol A
Study details
Groupmammalian
OrganismC57BL/6 mouse, male
Tissue
Age5 weeks
InVivoIn vivo
LabLaboratory
Flow
Duration8 weeks
RouteDrinking water
Temperature
Concentration50 µg/ml
NotesDose range: 0.5 and 50 µg/ml
Described effects
suspected endocrine effect
Decreased plasma free testosterone levels
suspected endocrine effect
Multinucleated giant cells in the seminiferous tubules of the testis
Literature references
Takao, T., Nanamiya, W., Nagano, I., Asabe, K., Kawabata, K., Hashimoto, K.(1999). Exposure with the environmental estrogen bisphenol A disrupts the male reproductive tract in young mice.Life Sci., 65: 2351-2357
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.