ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Bisphenol A
Study details
Groupmammalian
OrganismHuman
TissuePlasma
Age
InVivoIn vitro
LabLaboratory
Flow
Duration60 min
Route
Temperature37°C
Concentration
Notes
Described effects
suspected endocrine effect
IC50 for [3H]testosterone displacement from SHBG: 51 µM
suspected endocrine effect
IC50 for [3H]17-beta-estradiol displacement from SHBG: 13.6 µM
suspected endocrine effect
100 µM: 30% increase in non-SHBG-bound testosterone
suspected endocrine effect
100 µM: 16% increase in non-SHBG-bound 17-beta-estradiol
Literature references
Déchaud, H., Ravard, C., Claustrat, F., Brac de la Perričre, A., Pugeat, M.(1999). Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG).Steroids, 64: 328-334
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.