ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Dicofol (Kelthane)
Study details
Groupreptile
OrganismAlligator mississipiensis, female
TissueOviduct
AgeAdult
InVivoIn vitro
LabLaboratory
Flow
Duration1 hour
Route
Temperature25°C
ConcentrationIC50 = 45.6 µM
NotesER binding assay
Described effects
Effect on anti-estrogen: Inhibition of tritiated 17-beta-estradiol binding to ER
Literature references
Vonier, M.P., Crain, A.D., McLachlan, J.A., Guilette, L.J., Jr., Arnold, S.F.(1996). Interaction of Environmental Chemicals with the Estrogen and Progesterone Receptors from the oviduct of the American Alligator.Environ. Health Perspect., 104(12): 1318-1322
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.