ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Lindane (gamma-Hexachlorocyclohexane)
Study details
Groupmammalian
OrganismLong Evans rat, female
Tissue
Age21 days
InVivoIn vivo
LabLaboratory
Flow
Duration5 days
RouteOral
Temperature
Concentration10-40 mg/kg
NotesOvariectomized and 17-beta-estradiol-3-benzoate (EB)-primed
Described effects
suspected no endocrine effect
No effects on serum estradiol and uterine progesterone concentrations
suspected no endocrine effect
No effects on ER binding
suspected no endocrine effect
No effects on pituitary and uterus weight
Literature references
Laws, S.C., Carey, S.A., Hart, D.W., Cooper, R.L.(1994). Lindane does not alter the estrogen receptor or the estrogen-dependent induction of progesterone receptors in sexually immature or ovariectomized adult rats.Toxicology 92:127-142
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.