ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Lindane (gamma-Hexachlorocyclohexane)
Study details
Groupmammalian
OrganismFischer-344 rat, female
Tissue
Age21 days
InVivoIn vivo
LabLaboratory
Flow
DurationChronic
RouteIntraperitoneal
Temperature
Concentration5-40 mg/kg
Notes
Described effects
Effect on anti-estrogen: Delayed vaginal opening and disrupted ovarian cycle
Effect on anti-estrogen: Decreased serum and pituitary LH and prolactin levels
suspected endocrine effect
Decreased pituitary and uterus weight
Effect on anti-estrogen: Increased pituitary FSH levels
suspected endocrine effect
10 mg/kg: increased serum estrogen
suspected endocrine effect
40 mg/kg: decreased serum estrogen
Literature references
Cooper, R.L., Chadwick, R.W., Rehnberg, G.L., Goldman, J.M., Booth, K.C., Hein, J.F., McElroy, W.K.(1989). Effect of Lindane on Hormonal Control of Reproductive Function in the Rat.Toxicol. Appl. Pharmacol, 99: 384- 394
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.