ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Lindane (gamma-Hexachlorocyclohexane)
Study details
Groupmammalian
OrganismFischer-344 rat, female
Tissue
Age21 days
InVivoIn vivo
LabLaboratory
Flow
DurationChronic
RouteIntraperitoneal
Temperature
Concentration5-40 mg/kg
NotesDay 21-28: subcutaneous injection of 10 µg estradiol benzoate
Described effects
Effect on anti-estrogen: Lower estradiol benzoate induced increase in serum LH
suspected endocrine effect
Decreased uterus weight
Effect on anti-estrogen: Smaller estradiol benzoate induced decrease in pituitary LH, FSH and prolactin
Literature references
Cooper, R.L., Chadwick, R.W., Rehnberg, G.L., Goldman, J.M., Booth, K.C., Hein, J.F., McElroy, W.K.(1989). Effect of Lindane on Hormonal Control of Reproductive Function in the Rat.Toxicol. Appl. Pharmacol, 99: 384- 394
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.