ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Lindane (gamma-Hexachlorocyclohexane)
Study details
Groupmammalian
OrganismFischer-344 rat, female
Tissue
Age21 days
InVivoIn vivo
LabLaboratory
Flow
DurationChronic
RouteIntraperitoneal
Temperature
ConcentrationLOEL = 40 mg/kg/day
NotesCocncentration range: 5-40 mg/kg/day
Described effects
Effect on anti-estrogen: Delayed vaginal opening and disrupted ovarian cycle
suspected endocrine effect
Reduced pituitary and uterus weight
Literature references
Chadwick, R.W., Cooper, R.L., Chang, J., Rehnberg, G.L., McElroy, W.K.(1988). Possible antiestrogenic activity of Lindane in Female Rats.J. Biochem. Toxicol., 3: 147-158
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.