ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Lindane (gamma-Hexachlorocyclohexane)
Study details
Groupmammalian
OrganismRat, male offspring
Tissue
Age
InVivoIn vivo
LabLaboratory
Flow
Duration
RouteMother milk
Temperature
Concentration6 mg/kg
NotesSingle dose to mother on day 9 or 14 of lactation
Described effects
suspected endocrine effect
At adulthood: reduced testicular weight
Effect on anti-androgen: At adulthood: reduced number of sperm and spermatids
Effect on anti-androgen: At adulthood and puberty: reduced serum testosterone levels
Literature references
Dalsenter, P.R., Faqi, A.S., Webb, J., Merker, H.J., Chahoud, I.(1997). Reproductive Toxicity and Toxicokinetics of Lindane in the Male Offspring of Rats Exposed during Lactation.Hum. Exp. Toxicol., 16: 146-153
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.