ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Lindane (gamma-Hexachlorocyclohexane)
Study details
Groupmammalian
OrganismEwe
Tissue
Age1-4 years
InVivoIn vivo
LabLaboratory
Flow
Duration43 days
RouteOral
Temperature
Concentration2.5 mg/kg
NotesDosing by gelatin capsules 2 times weekly
Described effects
Effect on estrogen: Increased serum estradiol levels
Effect on thyroid hormone: Decreased serum T4 levels
Effect on insulin: Increased serum insulin levels
Effect on gonadotropin: Decreased basal serum LH levels
Literature references
Rawlings, N.C., Cook, S.J., Waldbillig, D.(1998). Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2,4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes.J. Toxicol. Env. Health, Part A, 54: 21-36
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.