ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Atrazine
Study details
Groupmammalian
OrganismRat
Tissue
AgePrenatal
InVivoIn vivo
LabLaboratory
Flow
Duration
RouteSubcutaneous
Temperature
Concentration16 mg/kg bodyweight
Notes
Described effects
suspected endocrine effect
Female pups: increased 5-alpha-steroid reductase activity
suspected no endocrine effect
Female pups: no effects on pituitary androgen metabolism
suspected endocrine effect
Male pups: decreased 3-alpha-hydroxysteroid dehydrogenase and 5-alpha-steroid reductase
suspected endocrine effect
Male pups: decreased number of androgen-specific binding sites in prostate
suspected no endocrine effect
Male pups: no effects pituitary metabolism
Literature references
Toppari,J., Larsen, J.C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L.J., Jr., Jégou, B., Jensen, T.K., et al.(1995). Male reproductive health and environmental chemicals with estrogenic effects.Miljoprojekt nr. 290, Report of the Ministry of Environmental and Energy, Danish Environmental Protection Agency, Kobenhavn, Denmark, 166p
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.