ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Atrazine
Study details
Groupmammalian
OrganismLong-Evans hooded rat
TissueOvary
AgeFemales with regular 4-day cycles
InVivoIn vivo
LabLaboratory
Flow
Duration21 days
RouteOral
Temperature
Concentration75-300 mg/kg/day
Notes
Described effects
Effect on estrogen: 75 mg/kg: disrupted 4-day ovarian cycle
Effect on estrogen: 150 mg/kg: repetitive pseudopregnancies
suspected no endocrine effect
300 mg/kg: regression of ovaries and anestrous condition
Literature references
Cooper, R.L., Stoker, T.E., Goldman, J.M., Parrish, M.B., Tyrey, L.(1996). Effect of atrazine on ovarian function in the rat.Reprod. Toxicol., 10: 257-264
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.