ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Atrazine
Study details
Groupmammalian
OrganismRat
TissuePC12 cells
Age
InVivoIn vitro
LabLaboratory
Flow
Duration6-24 hours
Route
Temperature
Concentration12.5-200 µM
NotesRat adrenal pheochromocytoma cellc
Described effects
Effect on catecholamine: Dose-dependent inhibition of TH-mediated dopamine synthesis
Effect on catecholamine: 100-200 µM: dose-dependent inhibition of DbH-mediated norepinephrine synthesis
suspected no endocrine effect
200 µM: reduced cell viability at 24 hours of exposure
Literature references
Das, P.C., McElroy, W.K., Cooper, R.L.(2000). Differential modulation of catecholamines by chlorotriazine herbicides in pheochromocytoma (PC12° cells in vitro.Toxicol. Sci., 56: 324-331
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
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