ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Simazine
Study details
Groupmammalian
OrganismSprague-Dawley rat, female
TissueUterus
Age19 days
InVivoIn vivo
LabLaboratory
Flow
Duration3 days
RouteInjection
Temperature
Concentration50-300 mg/kg/day
Notes
Described effects
suspected no endocrine effect
No induction of ER-mediated responses
Literature references
Connor, K., Howell, J., Chen, I., Liu, H., Berhane, K., Sciarretta, C., Safe, S., Zacharewski, T.(1996). Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro.Fundam. Appl. Toxicol., 30: 93-101
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.