ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Simazine
Study details
Groupmammalian
OrganismFisher 344 rat, female
Tissue
Age10-13 weeks
InVivoIn vivo
LabLaboratory
Flow
Duration2 weeks
RouteOral
Temperature
Concentration100-300 mg/kg/day
Notes
Described effects
suspected endocrine effect
Decrease of days in estrus, increase of days in diestrus
Effect on anti-estrogen: Decrease in circulating estradiol levels
Literature references
Eldridge, J.C., Fleenor-Heyser, D.G., Extrom, P.C., Wetzel, L.T., Breckenridge, C.B., Gillis, J.H. et al.(1994). Short-term effects of chlorotriazines on estrus in female Sprague-Dawley and Fischer 344 rats.J. Toxicol. Environ. Health, 43:155-167
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.