ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Alachlor
Study details
Groupmammalian
OrganismLong-Evans rat, male
Tissue
Age12 weeks
InVivoIn vivo
LabLaboratory
Flow
Duration120 days
RouteFood
Temperature
Concentration126 mg/kg body weight/day
NotesEndpoints measured on day 7, 14, 28, 60 and 120
Described effects
Effect on gonadotropin releasing hormone: Increase in circulating TSH levels from day 7 (reversible)
Effect on gonadotropin: Decrease in circulating T4 levels from day 7
Effect on gonadotropin: Increase in circulating T3 levels (reversible)
suspected endocrine effect
Increased thyroid weight
Literature references
Wilson, A.G.E., Thake, D.C., Heydens, W.E., Brewster, D.W., Hotz, K.J.(1996). Mode of Action of Thyroid Tumor Formation in the Male Long-Evans Rat Administered High Doses of Alachlor.Fundam. Appl. Toxicol., 33: 16-23
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.