ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Alachlor
Study details
Groupmammalian
OrganismHuman
TissueTRbeta
Age
InVivoIn vitro
LabLaboratory
Flow
Duration
Route
Temperature
ConcentrationKi > 100 µM
NotesSf9 insect cells transfected with human Trbeta
Described effects
Effect on thyroid hormone: Very low affinity for TRbeta
Effect on thyroid hormone: 100 µM: 20% displacement of tritiated T3 from TR
Literature references
Cheek, A.O., Kow, K., Chen, J., McLachlan, J.A.(1999). Potential mechanisms of thyroid disruption in humans: Interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin.Environ. Health Perspect., 107: 272-278
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.