ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Hexachlorobenzene
Study details
Groupmammalian
OrganismICR mouse, male
Tissue
AgeAdult
InVivoIn vivo
LabLaboratory
Flow
Duration21 days
RouteFood
Temperature
Concentration250 mg/kg/food
NotesConcentration range: 2.5-250 mg/kg/food
Described effects
suspected endocrine effect
Decreased serum testosterone concentrations
suspected endocrine effect
Increased in vitro hepatic microsomal testosterone metabolism
Literature references
Elissalde, M.H., Clark, D.E.(1979). Testosterone metabolism by hexachlorobenzene-induced hepatic microsomal enzymes.Am. J. Vet. Res., 40: 1762-1766
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.