ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Hexachlorobenzene
Study details
Groupmammalian
OrganismWistar rat, female
Tissue
AgeAdult
InVivoIn vivo
LabLaboratory
Flow
Duration13 weeks
RouteFood
Temperature
Concentration9.5 mg/kg body weight/day
Notes
Described effects
Effect on thyroid hormone: Decreased serum levels of total and free T3
Effect on thyroid hormone: Decreased serum levels of total and free T4
Effect on retinoid hormone: Disturbed retinoid hormone homeostasis
Literature references
den Besten, C., Bennik, M.H., Bruggeman, I., Schielen, P., Kuper, F., Brouwer, A., Koeman, J.H., Vos, J.G., van Bladeren, J.(1993). The role of oxidative metabolism in hexacholorobenzene-induced porphyria and thyroid hormone homeostasis: A comparison with pentachlorobenzene in a 13-week feeding study.Toxicol. Appl. Pharmacol., 119: 181-194
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.