ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
PCB
Study details
Groupmammalian
OrganismSprague-Dawley rat, female
Tissue
Age21 days
InVivoIn vivo
LabLaboratory
Flow
Duration2 days
RouteIntraperitoneal
Temperature
Concentration6-175 mg/kg
NotesAir extracts containing PCBs, PCDFs, PCDDs
Described effects
suspected endocrine effect
Increased hepatic P450 enzyme activities
Effect on thyroid hormone: 12 mg/kg: increased serum total T4
Effect on thyroid hormone: 38-175 mg/kg: decreased serum total T4
Literature references
Li, M.H., Hansen, L.G.(1996). Enzyme induction and acute endocrine effects in prepubertal female rats receiving environmental PCB/PCDF/PCDD mixtures.Environ. Health Perspect., 104: 712-722
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.