ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
2,2',4,4',5-Pentabromodiphenyl ether (BDE 99)
Study details
Groupmammalian
OrganismMouse
TissueAdrenocortical Y1 cells
Age
InVivoIn vitro
LabLaboratory
Flow
Duration24 hours
Route
Temperature
Concentration20 µM
Notes
Described effects
suspected no endocrine effect
No significant inhibition of CYP11B1-dependent corticosterone synthesis
Literature references
Johansson, M., Larsson, C., Bergman, A., Lund, B.O.(1998). Structure-activity relationship for inhibition of CYP11B1-dependent glucocorticoid synthesis in Y1 cells by aryl methyl sulfones.Pharmacol. Toxicol., 83: 225-230
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.