ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
home login contact pictures
 
planning background results databases partners users
ED North Database
2,2',4,4',5-Pentabromodiphenyl ether (BDE 99)
Study details
Groupmammalian
OrganismHuman
Tissue
Age
InVivoIn vitro
LabLaboratory
Flow
DurationOvernight
Route
Temperature4°C
ConcentrationMetabolites: max 250 nM
NotesMetabolization by incubation with rat hepatic microsomes prior to use; max concentration with 100% conversion; T4-transthyretin competition binding study
Described effects
suspected no endocrine effect
No significant displacement of T4 from transthyretin
suspected no endocrine effect
Parent PBDE: no binding to transthyretin
Literature references
Meerts, I.L.T.M., van Zanden, J.J., Luijks, E.A.C., van Leeuwen-Bol, I., Marsh, G., Jakobsson, E., Bergman, A., Brouwer, A.(2000). Potent competitive interactions of some brominated flame retartands and related compounds with human transthyretin in vitro.Toxicol. Sci., 56: 95-104
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.