ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Cadmium
Study details
Groupmammalian
OrganismSprague-Dawley rat, male
Tissue
AgePostpubertal (60 days)
InVivoIn vivo
LabLaboratory
Flow
Duration30 days
RouteSubcutaneous
Temperature22°C
Concentration0.5 or 1 mg/kg body weight
NotesDosing from days 60 to 90 every 4 days in an alternate schedule
Described effects
Effect on gonadotropin: Decreased plasma FSH levels
Effect on neurohormone: Decreased 5-HT levels in hypothalamus
Effect on neurohormone: Increased 5-HT turnover in anterior and posterior hypothalamus
Effect on anti-androgen: Decreased plasma testosterone levels
suspected endocrine effect
Age dependent accumulation of Cd in hypothalamus, pituitary and testes
Effect on catecholamine: Decreased NE levels in anterior and mediobasel hypothalamus and median eminence
Literature references
Lafuente, A., Marquez, N., Pérez-Lorenzo, M., Pazo, D., Esquifino, A.I.(2000). Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat.Food Chem. Toxicol., 38: 913-923
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.