ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Methoxychlor
Study details
Groupfish
OrganismIctalurus punctatus (Channel catfish), female
TissueLiver
Age2 years
InVivoIn vitro
LabLaboratory
Flow
Duration5 hours
Route
TemperatureRoom temperature
ConcentrationIC50 = 14.23 µM
Notes
Described effects
Effect on estrogen: Inhibition of radiolabeled estradiol binding to ER; relative potency (%) to estradiol: 0.015
Literature references
Nimrod, A.C., Benson, W.H.(1997). Xenobiotic Interaction with and Alteration of Channel Catfish Estrogen Receptor.Toxicol. Apl. Pharmacol., 147: 381-390
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.