ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Methoxychlor
Study details
Groupmammalian
OrganismMouse
TissueUterus
AgeAdult
InVivoIn vivo
LabLaboratory
Flow
Duration18 hours
RouteSubcutaneous
Temperature
Concentration3.75-60 mg/kg body weight
NotesConcentration range: 1.8-60 mg/kg body weight; 2 injections 6 h apart
Described effects
Effect on estrogen: Increased estrogen responsive transcription of LF and G6PD mRNA transcription
Literature references
Ghosh, D., Taylor, J.A., Green, J.A., Lubahn, D.B.(1999). Methoxychlor stimulates estrogen-responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER)alpha and non ERbeta mechanism.Endocrinology, 140: 3526-3533
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.