ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Methoxychlor
Study details
Groupfish
OrganismIctalurus punctatus (Channel catfish), female
TissueLiver
Age14 months
InVivoIn vitro
LabLaboratory
Flow
Duration
Route
Temperature
ConcentrationIC50 = 78 µM
Notes
Described effects
Effect on estrogen: Inhibition of radiolabeled estradiol binding to ER
Effect on estrogen: Relative potency to 17-beta-estradiol: 0.00002
Literature references
Schlenk, D., Stresser, D.M., Rimoldi, J., Arcand, L., McCants, J., Nimrod, A.C., Benson, W.H.(1998). Biotransformation and estrogenic activity of methoxychlor and its metabolites in channel catfish (Ictalurus punctatus).Mar. Environ. Res., 46: 159-162
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.