ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Methoxychlor
Study details
Groupmammalian
OrganismCD-1 mouse, female
TissueUterus
Age21 days
InVivoIn vivo
LabLaboratory
Flow
Duration3 days
RouteSubcutaneous
Temperature
Concentration0.5-500 mg/kg body weight/day
NotesMarkers for uterotrophic effects: uterine peroxidase activity, BrdU incorporation as index of cell proliferation, LF expression
Described effects
Effect on estrogen: 0.5-500 mg/kg: increased relative uterus weight
Effect on estrogen: 100-500 mg/kg: increased peroxidase activity
Effect on estrogen: 500 mg/kg: induction of cell proliferation
Literature references
Mehmood, Z., Smith, A.G., Tucker, M.J., Chuzel, F., Carmichael, N.G.(2000). The development of methods for assessing the in vivo oestrogen-like effects of xenobiotics in CD-1 mice.Food Chem. Toxicol., 38: 493-501
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.