ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Methoxychlor
Study details
Groupmammalian
OrganismRabbit
TissueER
Age
InVivoIn vitro
LabLaboratory
Flow
Duration18-20 hours
Route
Temperature4°C
ConcentrationIC50 = 6.5 µM
NotesEstrogen receptor binding assay
Described effects
Effect on estrogen: Inhibition of tritiated 17-beta-estradiol binding to ER
Effect on estrogen: Relative binding affinity: 0.0000031
Literature references
Andersen, H.E., Andersson, A.M., Arnold, S.F., Autrup, H., Barfoed, M., Beresford, N.A., Bjerregaard, P. et al.(1999). Comparison of short-term estrogenicity tests for identification of hormone-disrupting chemicals.Environ. Health Perspect., 107 (suppl. 1): 89-108
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.