ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Methoxychlor
Study details
Groupmammalian
OrganismHuman
TissueERalpha
Age
InVivoIn vitro
LabLaboratory
Flow
Duration1 hour
Route
TemperatureRoom temperature
ConcentrationIC50 = 81-193 µM
NotesFluorescence polarization method to measure ER binding
Described effects
Effect on estrogen: Inhibition of fluorescent ligand ES1 binding to ER
Effect on estrogen: RBA compared to estradiol: 0.007-0.02%
Literature references
Bolger, R., Wiese, T.E., Ervin, K., Nestich, S., Checovich, W.(1998). Rapid screening of environmental chemicals for estrogen receptor binding capacity.Environ. Health Perspect., 106: 551-557
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.