ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Methoxychlor
Study details
Groupmammalian
OrganismHuman
TissueHepG2 hepatoma cells
Age
InVivoIn vitro
LabLaboratory
Flow
Duration
Route
Temperature
Concentration0.01-10 µM
NotesAndrogen receptor assay
Described effects
Effect on anti-androgen: Inhibition of DHT-induced activity (antagonist)
Literature references
Maness, S.C., McDonnell, D.P., Gaido, K.W.(1998). Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.Toxicol. Appl. Pharmacol., 151: 135-142
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.