ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Tetrabromobisphenol A
Study details
Groupmammalian
OrganismHuman
Tissue
Age
InVivoIn vitro
LabLaboratory
Flow
DurationOvernight
Route
Temperature4°C
ConcentrationIC50 = 7.7 nM
NotesT4-transthyretin competition binding study
Described effects
Effect on thyroid hormone: Displacement of T4 from transthyretin
Literature references
Meerts, I.L.T.M., van Zanden, J.J., Luijks, E.A.C., van Leeuwen-Bol, I., Marsh, G., Jakobsson, E., Bergman, A., Brouwer, A.(2000). Potent competitive interactions of some brominated flame retartands and related compounds with human transthyretin in vitro.Toxicol. Sci., 56: 95-104
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
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