ED North Database | Lindane (gamma-Hexachlorocyclohexane) |
Study details | Group | mammalian | Organism | Long Evans rat, female | Tissue | | Age | 60 days | InVivo | In vivo | Lab | Laboratory | Flow | | Duration | 5 days | Route | Oral | Temperature | | Concentration | 10-40 mg/kg | Notes | Ovariectomized and 17-beta-estradiol-3-benzoate (EB)-primed |
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Described effects | | suspected no endocrine effect No effects on serum estradiol concentrations | | suspected no endocrine effect No effects on pituitary weight | | suspected no endocrine effect No effets on ER distribition and PR binding |
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Literature references | Laws, S.C., Carey, S.A., Hart, D.W., Cooper, R.L.(1994). Lindane does not alter the estrogen receptor or the estrogen-dependent induction of progesterone receptors in sexually immature or ovariectomized adult rats.Toxicology 92:127-142 |
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