ED North Database | Lindane (gamma-Hexachlorocyclohexane) |
Study details | Group | mammalian | Organism | Fischer-344 rat, female | Tissue | | Age | 21 days | InVivo | In vivo | Lab | Laboratory | Flow | | Duration | Chronic | Route | Intraperitoneal | Temperature | | Concentration | 5-40 mg/kg | Notes | |
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Described effects | | Effect on anti-estrogen: Delayed vaginal opening and disrupted ovarian cycle | | Effect on anti-estrogen: Decreased serum and pituitary LH and prolactin levels | | suspected endocrine effect Decreased pituitary and uterus weight | | Effect on anti-estrogen: Increased pituitary FSH levels | | suspected endocrine effect 10 mg/kg: increased serum estrogen | | suspected endocrine effect 40 mg/kg: decreased serum estrogen |
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Literature references | Cooper, R.L., Chadwick, R.W., Rehnberg, G.L., Goldman, J.M., Booth, K.C., Hein, J.F., McElroy, W.K.(1989). Effect of Lindane on Hormonal Control of Reproductive Function in the Rat.Toxicol. Appl. Pharmacol, 99: 384- 394 |
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