ED North Database | Lindane (gamma-Hexachlorocyclohexane) |
Study details | Group | mammalian | Organism | Ewe | Tissue | | Age | 1-4 years | InVivo | In vivo | Lab | Laboratory | Flow | | Duration | 43 days | Route | Oral | Temperature | | Concentration | 2.5 mg/kg | Notes | Dosing by gelatin capsules 2 times weekly |
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Described effects | | Effect on estrogen: Increased serum estradiol levels | | Effect on thyroid hormone: Decreased serum T4 levels | | Effect on insulin: Increased serum insulin levels | | Effect on gonadotropin: Decreased basal serum LH levels |
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Literature references | Rawlings, N.C., Cook, S.J., Waldbillig, D.(1998). Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2,4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes.J. Toxicol. Env. Health, Part A, 54: 21-36 |
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