ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Simazine
Study details
Groupmammalian
OrganismRat
TissuePC12 cells
Age
InVivoIn vitro
LabLaboratory
Flow
Duration6-24 hours
Route
Temperature
Concentration50-200 µM
NotesRat adrenal pheochromocytoma cellc; dose range: 12.5-200 µM
Described effects
Effect on catecholamine: Dose-dependent inhibition of TH-mediated dopamine synthesis
Effect on catecholamine: 100-200 µM: dose-dependent inhibition of DbH-mediated norepinephrine synthesis
Literature references
Das, P.C., McElroy, W.K., Cooper, R.L.(2000). Differential modulation of catecholamines by chlorotriazine herbicides in pheochromocytoma (PC12° cells in vitro.Toxicol. Sci., 56: 324-331
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.