ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Cadmium
Study details
Groupmammalian
OrganismSprague-Dawley rat, male
Tissue
AgePubertal (30 days)
InVivoIn vivo
LabLaboratory
Flow
Duration30 days
RouteSubcutaneous
Temperature22°C
Concentration0.5 or 1 mg/kg body weight
NotesDosing from days 30 to 60 every 4 days in an alternate schedule
Described effects
Effect on neurohormone: Decreased 5-HT levels in hypothalamus
Effect on neurohormone: Increased 5-HT turnover in anterior hypothalamus and median eminence
Effect on androgen: Increased plasma testosterone levels
suspected endocrine effect
Age dependent accumulation of Cd in hypothalamus and testes
Effect on catecholamine: Increased NE levels in hypothalamus
Effect on catecholamine: Decreased NE levels in median eminence
Literature references
Lafuente, A., Marquez, N., Pérez-Lorenzo, M., Pazo, D., Esquifino, A.I.(2000). Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat.Food Chem. Toxicol., 38: 913-923
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.