ED North Database | Cadmium |
Study details | Group | mammalian | Organism | Sprague-Dawley rat, male | Tissue | | Age | Postpubertal (60 days) | InVivo | In vivo | Lab | Laboratory | Flow | | Duration | 30 days | Route | Subcutaneous | Temperature | 22°C | Concentration | 0.5 or 1 mg/kg body weight | Notes | Dosing from days 60 to 90 every 4 days in an alternate schedule |
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Described effects | | Effect on gonadotropin: Decreased plasma FSH levels | | Effect on neurohormone: Decreased 5-HT levels in hypothalamus | | Effect on neurohormone: Increased 5-HT turnover in anterior and posterior hypothalamus | | Effect on anti-androgen: Decreased plasma testosterone levels | | suspected endocrine effect Age dependent accumulation of Cd in hypothalamus, pituitary and testes | | Effect on catecholamine: Decreased NE levels in anterior and mediobasel hypothalamus and median eminence |
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Literature references | Lafuente, A., Marquez, N., Pérez-Lorenzo, M., Pazo, D., Esquifino, A.I.(2000). Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat.Food Chem. Toxicol., 38: 913-923 |
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