ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Methoxychlor
Study details
Groupamphibian
OrganismXenopus laevis (African clawed frog)
TissueOvary
AgeAdult
InVivoIn vitro
LabLaboratory
Flow
Duration24 hours
Route
Temperature20-23°C
ConcentrationIC50 = 72 nM
NotesGerminal vesicle breakdown assay
Described effects
Effect on progestogen: Inhibition of progesterone-induced oocyte maturation
Literature references
Pickford, D.B., Morris, I.D.(1999). Effects of endocrine-disrupting contaminants on amphibian oogenesis: Methoxychlor inhibits progesterone-induced maturation of Xenopus laevis oocyte in vitro.Environ. Health Perspect., 107: 285-292
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.