ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Methoxychlor
Study details
Groupmammalian
OrganismRat
TissueER
Age
InVivoIn vitro
LabLaboratory
Flow
Duration
Route
Temperature
ConcentrationIC50 = 100 µM
NotesLigand competition binding assay; cytosolic ER of MtT/E-2 cells
Described effects
Effect on estrogen: Inhibition of tritiated 17-beta-estradiol binding to ER
Effect on estrogen: Potency relative to 17-beta-estradiol: 0.00001
Literature references
Maruyama, S., Fujimoto, N., Yin, H., Ito, A.(1999). Growth stimulation of a rat pituitary cell line MtT/E-2 by environmental estrogens in vitro and in vivo.Endocr. J., 46: 513-520
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.