ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Pentachlorophenol (PCP)
Study details
Groupyeast
OrganismYeast strain hPR-PRE
TissuePR
Age
InVivoIn vitro
LabLaboratory
Flow
DurationOvernight
Route
Temperature
ConcentrationIC50 = 350 µM
NotesConcentration range: 100 nM - 1 µM
Described effects
Effect on progestogen: Reduction of R5020 binding to hPR
Literature references
Tran, D.Z.., Klotz, D.M., Ladlie, B.L., Ide, C.F., McLachlan, J.A., Arnold, S.F.(1996). Inhibition of progesterone receptor activity in yeast by synthetic chemicals.Biochem. Biophys. Res. Commun., 229: 518-523
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.